GENOMIC IMPRINTING IN MAMMALS - A REVIEW

DOI: 10.5958/0976-0741.2014.00093.2    | Article Id: ARCC374 | Page : 148-152
Citation :- GENOMIC IMPRINTING IN MAMMALS - A REVIEW.Agricultural Reviews.2014.(35):148-152
Parul Gupta*, Dibyendu Chakraborty1, Raman Taggar, Dhirendra Kumar, Rajan Sharma and Vishav P. Singh drparulgupta24@gmail.com
Address : Division of Animal Genetics and Breeding SKUAST-J, R.S. Pura, Jammu-181 102, India

Abstract

Genomic imprinting refers to an epigenetic mark that distinguishes parental alleles and results in a monoallelic, parental-specific expression pattern in mammals. The alleles of imprinted genes are marked epigenetically as discrete elements termed imprinting control regions with their parental origin in gametes through the use of DNA methylation, at the very least. Imprinted genes are normally involved in foetal growth and behavioural development. Consequently, aberrant imprinting disturbs development and is the cause of numerous well-known imprinting disorders, including Beckwith-Wiedemann syndrome, Prader-Willi syndrome, Cancer and Angelman syndrome.

Keywords

DNA methylation Genetic disorders Imprinting Imprinted gene Mammals

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