Flavonoids: Biosynthesis, Metabolism, Mechanism of Antioxidation and Clinical Implications: A Review

DOI: 10.18805/ag.R-1922    | Article Id: R-1922 | Page : 227-237
Citation :- Flavonoids: Biosynthesis, Metabolism, Mechanism of Antioxidation and Clinical Implications: A Review.Agricultural Reviews.2020.(41):227-237
Address : Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara-144 011, Punjab, India.
Submitted Date : 16-07-2019
Accepted Date : 16-06-2020

Abstract

Flavonoids are the molecules derived from a core molecule flavan which are synthesized in plants and microbes by a complex process catalyzed by enzymes located in endoplasmic reticulum. These exist in human body in association with glycosides which can be absorbed in small intestine and are metabolized further in liver. This review consolidates the Biosynthesis of flavonoids in plant systems, its metabolism in human body, the role of different rings and groups on the antioxidant potential of flavonoids, the chemical mechanisms of its actions and finally clinical implications of these molecules against Alzheimer’s disease, Parkinson’s disease, cardiovascular diseases, diabetes, Osteoarthritis and Rheumatoid Arthritis and cancers.

Keywords

Alzheimer’s disease Antioxidant Arthritis Cardiovascular diseases Diabetes Flavonoids Parkinson’s disease

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