Agricultural Reviews

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Agricultural Reviews, volume 37 issue 3 (september 2016) : 186-195

Strategic treatment with immunomodulators to resolve endometritis in cow: A review

Pradip Sarkar*1, Manas Kumar Patra2, Harendra Kumar
1<p>Animal Reproduction Division,&nbsp;Indian Veterinary Research Institute, Izatnagar-243 122, U.P., India.</p>
Cite article:- Sarkar*1 Pradip, Patra2 Kumar Manas, Kumar Harendra (2016). Strategic treatment with immunomodulators to resolveendometritis in cow: A review . Agricultural Reviews. 37(3): 186-195. doi: 10.18805/ag.v37i3.3534.

Postpartum uterine infections result from uterine contamination with bacteria during parturition. The uterine infection implies adherence of pathogenic organisms to the mucosa, colonization or penetration of the epithelium, and release of bacterial toxins that lead to establishment of uterine diseases. Treatment of endometritis with parenteral or intra-uterine infusion of the antibacterial agents and antibiotics have met with varying degree of success but inconsistence of recovery rate, high cost of treatment, milk disposal after antibiotic therapy, immergence of microbial resistance are obvious disadvantage of their use. They also markedly destroy the phagocytic activity of polymorphonuclear leucocytes, which are responsible for maintaining non-specific uterine defence. So, there is urgent need to find out an alternative therapy for treatment of uterine infections by activation of natural defence mechanism in the uterus. Prospects in use of certain non-specific immunomodulators in routine therapeutic protocol for endometritis and other uterine disorders is reviewed in present studies.

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