APPLICATIONS AND IMPLICATIONS OF MAMMALIAN ANTIMICROBIAL PEPTIDES- A REVIEW

DOI: 10.5958/0976-0741.2014.00918.0    | Article Id: R-1458 | Page : 299 - 306
Citation :- APPLICATIONS AND IMPLICATIONS OF MAMMALIAN ANTIMICROBIAL PEPTIDES- A REVIEW.Agricultural Reviews.2014.(35):299 - 306
Shahid Hussain, C.S. Mukhopadhyay* and J.S. Arora csmscience@gmail.com
Address : Post Graduate Institute of Veterinary Education and Research, Guru Angad Dev Veterinary and Animal University, Ludhiana-141 001, India

Abstract

Antimicrobial peptides are host defense peptides that are present in members of both Kingdoms Plantae vis-à-vis Animalia. These comprise of a number of structurally diverse peptides which are upto100 amino acid in length. These antimicrobial peptides are part of the inherent innate immune system of the host and are responsible for carrying out diverse activities ranging from killings the invading pathogens, modifying and regulating the immune system in executing these processes. In the immune system they have diverse functions such as acting as chemotaxis, modulation of inflammation, regulation of expression of inflammatory cytokines preventing hypersensitivity. Antimicrobial peptides are presently under trials for development of novel antibiotics which can be used for treatment of multidrug resistant pathogens. Currently different antimicrobial peptides are used as food preservatives and for prevention of microbes, like methicillin resistant S. aureus among others.

Keywords

Antimicrobial peptides Antibiotics Biological activity Immunomodulation Vaccine adjuvants

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