Agricultural Reviews

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Agricultural Reviews, volume 32 issue 2 (june 2011) : 79 - 90

BOVINE COLOSTRUM AND NEONATE IMMUNITY - A REVIEW

A.K. Singh*, S. Pandita, M.M. Vaidya, S.V. Singh, G. Chandra, Z.A. Pampoori, R. Huozha, M.M. Pathan, R. Kushwaha1, V.K. Sharma1
1Dairy Cattle Physiology Division National Dairy Research Institute,Karnal - 132 001, India
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Cite article:- Singh* A.K., Pandita S., Vaidya M.M., Singh S.V., Chandra G., Pampoori Z.A., Huozha R., Pathan M.M., Kushwaha1 R., Sharma1 V.K. (2024). BOVINE COLOSTRUM AND NEONATE IMMUNITY - A REVIEW. Agricultural Reviews. 32(2): 79 - 90. doi: .
Raising healthy calves with minimum mortality is crucial in successful dairying. The calf has essentially no immune protection at birth because maternal immunoglobulins cannot cross the placenta, and the calf's own immune system is functionally immature. Reducing health problems in calves can be achieved through feeding colostrum. The calf's acquisition of colostral immunoglobulins through absorption in the intestine is called passive transfer or passive immunity. In addition to disease protection, colostrum also provides the neonatal calf with high quality nutrition and many growth factors and hormones that may be beneficial for initiating function and growth of the digestive tract. "Failure of passive transfer" (FPT) occurs when the acceptable levels of IgG or total protein are not achieved by 24-48 hrs after birth. Timely and adequate colostrum intake is the single most important management factor affecting morbidity and mortality in preweaned calves. The two most important factors affecting the amount of IgG absorbed from colostrum are the time of first feeding and the amount of IgG consumed. In our experiment we found that the IgG > 10g/L was optimal for survival of buffalo neonatal.
  1. Arthington, J. D., M. B. Cattell, and J. D. Quigley, III. 2000a. Effect of dietary IgG sourceb(colostrum, serum, or milk-derived supplement) on the efficiency of Ig absorption in newborn Holstein calves. J. Dairy Sci. 83 :1463-1467.
  2. Arthington, J. D., M. B. Cattell, J. D. Quigley, III, G. C. McCoy, and W. L. Hurley. 2000b. Passive immunoglobulin transfer in newborn calves fed colostrum or spray-dried serum protein alone or as a supplement to colostrum of varying quality. J. Dairy Sci. 83 : 2834-2838.
  3. Besser, T. E. 1993. Concentrations of passively acquired IgG1 antibodies in the intestinal lumen of the neonatal calf. Vet. Immunol. Immunopathol. 38 : 103-112.
  4. Besser, T. E., McGuire, T. C., Gay, C. C. and Pritchett, L. C. 1988. Transfer of functional immunoglobulin G (IgG) antibody into the gastrointestinal tract accounts for IgG clearance in calves. J. Virol. 62 : 2234-2237.
  5. Boutinaud, M. and Jammes, H. 2002. Potential uses of milk epithelial cells: A review. Reprod. Nutr. Dev. 42: 133-147.
  6. Bush, L. J., and Staley, T. E. 1980. Absorption of colostral immunoglobulins in newborn calves. J. Dairy Sci. 63 : 672-680.
  7. Butler, J. E. 1969. Bovine immunoglobulins: a review. J. Dairy Sci. 52 : 1895-1909.
  8. Butler, J. E. 1983. Bovine immunoglobulins: an augmented review. Vet. Immunol. Immunopathol. 4 : 43-152.
  9. Chelack, B. J., P. S. Morley, and D. M. Haines. 1993. Evaluation of methods for dehydration of bovine colostrum for total replacement of normal colostrum in calves. Can. Vet. J. 34 : 407- 412.
  10. Comline, R. S., H. E. Roberts, and D. A. Titchen. 1951. Histological changes in the epithelium of the small intestine during protein absorption in the newborn animal. Nature (Lond.) 168 : 84-85.
  11. Crawford, M. L., J. D. Quigley, III, and K. R. Martin. 1995. Immunoglobulin concentrations in serum in response to injectable immunoglobulin in neonatal dairy calves. J. Dairy Sci. 78 : 1567-1572.
  12. Dang, A. K., Kapila, S., Purohit, M. and Singh, C. 2009. Changes in colostrum of Murrah buffaloes after calving. Trop. Anim. Health. Prod. 41: 1213-1217.
  13. Davis, C. L. and Drackley, J. K. 1998. The development, nutrition, and management of the young calf. Iowa State University Press. pp.188-189.
  14. Deutsch, H. F. and Smith, V. R. 1957. Intestinal permeability to proteins in herbivores. Am. J. Physiol. 191: 271.
  15. Devery, J. E., C. L. Davis, and B. L. Larson. 1979. Endogenous production of immunoglobulin IgG1 in newborn calves. J. Dairy Sci. 62: 1814-1818.
  16. Devery-Pocius, J. E. and B. L. Larson. 1983. Age and previous lactations as factors in the amount of bovine colostral immunoglobulins. J. Dairy Sci. 66: 221-225.
  17. Donovan,G. A., Badinga, L., Collier, R. J., Wilcox, C. J. and Braun, R. K.1986. Facters influencing passive transfer in dairy calves. J. Dairy Sci. 69: 754-75
  18. Foley, J. A. and D. E. Otterby. 1978. Availability, storage, treatment, composition, and feeding value of surplus colostrum: a review. J. Dairy Sci. 61: 1033-1060.
  19. Ganovski, K. H. 1979. Changes in the composition of the colostrum from cows and buffaloes and its significance in the nutrition of newborn calves. Vet. Med. Nauki. 16: 3-6.
  20. Garry, F. B., Adams, R. Cattell, M. B. and Dinsmore, R. P. 1996. Comparison of passive immunoglobulin transfer to dairy calves fed colostrum or commercially available colostralsupplement products. JAVMA. 208 : 107-110.
  21. Gopal, P. K., Gill, H. S. 2000. Oligosaccharides and glycoconjugates in bovine milk and colostrums. Br. J. Nutr. 84 : S69-S74.
  22. Hardy, R. N. 1969. Proteolytic activity during the absorption of [131I] -globulin in the newborn calf. J. Physiol. (Lond.) 205 : 453-470.
  23. Heinrichs, A. J. 1985. Feeding the newborn dairy calf. Spec. Circ. 311, Pennsylvania State Univ., University Park.
  24. Heinrichs, A. J., S. J. Wells, H. S. Hurd, G. W. Hill, and D. A. Dargatz. 1994. The national dairy heifer evaluation project: a profile of heifer management practices in the United States. J. Dairy Sci. 77 : 1548-1555.
  25. Holloway, N. M., Tyler, J. W., Lakritz, J., Carlson, S. L. and Holle, J. 2001. Serum immunoglobulin G concentrations in calves fed fresh and frozen colostrum. J. Am. Vet. Med. Assoc. 219 : 357-359.
  26. Huang, Y., Shao, X. M., Neu, J. 2003. Immunonutrients and neonates. Eur. J. Pediatr. 162 : 122-128.
  27. Husband, A. J., Brandon, M. R. and Lascelles, A. K. 1972. Absorption and endogenous production of immunoglobulins in calves. Aust. J. Exp. Biol. Med. Sci. 50 : 491-498.
  28. Inemani, O., Shiga, A., Okada,K., Sato, R., Miyake, Y. I and Kuwabara,M. 1999. Lipid peroxides and antioxidants in serum of neonatal calves. J. Vet. Res. 60 : 452-457.
  29. James, R. E., C. E. Polan, and M. L. McGilliard. 1979. Distributional uptake of-globulin in the small intestine of neonatal calves. J. Dairy Sci. 62 : 1415-1419.
  30. Jochims, K., F. J. Kaup, W. Drommer, and M. Pickel. 1994. An immunoelectron microscopic investigation of colostral IgG absorption across the intestine of newborn calves. Res. Vet. Sci. 57 : 75-80.
  31. Jones, L. R., A. W. Taylor, and H. C. Hines. 1987. Characteristics of frozen colostrums thawed in a microwave oven. J. Dairy Sci. 70 : 1941-1945.
  32. Kelly, G. 2003. Bovine colostrums: A review of clinical uses. Altern. Med. Rev. 8 : 78-394.
  33. Koldovsky, O. 1989. Search for role of milk-borne biologically active peptides for the suckling. J. Nutr. 119 : 1543-1551.
  34. Kruse, V. 1970. Absorption of immunoglobulin from colostrum in newborn calves. Anim. Prod. 12 : 627-638.
  35. Kume, S. and S. Tanabe. 1993. Effect of parity on colostral mineral concentrations of Holstein cows and value of colostrum as a mineral source for newborn calves. J. Dairy Sci. 76 : 1654-1660.
  36. Larson, B. L., Heary, H. L. and Devery, J. E. 1980. Immunoglobulin production and transport by the mammary gland. J. Dairy Sci. 63 : 665-671.
  37. Levy, M., Maurey, C., Dinh-Xuan, A. T., Vouhe, P., Israel-Biet, D. 2005. Developmental expression of vasoactive and growth factors in human lung. Role in pulmonary vascular resistance adaptation at birth. Pediatr. Res. 57: 21R-25R.
  38. Lilius, E. M., and Marnila, P. 2001. The role of colostral antibodies in prevention of microbial infections. Curr. Opin. Infect. Dis. 14 : 295-300.
  39. Logan, E. F., McBeath, D. G. and Lowman, B. G. 1974. Quantitative studies on serum immunoglobulin levels in suckled calves from birth to five weeks. Vet. Rec. 94: 367-370.
  40. Matte, J. J., Girard, C. L., Seoane, J. R. and Brisson, G. J. 1982. Absorption of colostral immunoglobulin G in the newborn calf. J. Dairy Sci. 65 : 1765-1770.
  41. Maunsell, F. P., D. E. Morin, P. D. Constable, W. L. Hurley, G. C. McCoy, I. Kakoma, and R. E. Isaacson. 1998. Effects of mastitis on the volume and composition of colostrums produced by Holstein cows. J. Dairy Sci. 81 : 1291-1299.
  42. McEwan, A. D., Fisher, E. W. and Selman, I. E. 1970. An estimation of the efficiency of the absorption of immune globulins from colostrum by newborn calves. Res. Vet. Sci. 11 : 239.
  43. McEwan, A. D., Fisher, E. W. and Selman, I. E. 1968. The effect of colostrum on the volume and composition of the plasma of calves. Res. Vet. Sci. 9 : 284.
  44. McGuire, T. C., Pfeiffer, N. E., Weikel, J. M. and Bartsch, R. C. 1976. Failure of colostral immunoglobulin transfer in calves dying from infectious disease. J. Amer. Vet. Med. Assoc. 169 : 713.
  45. Mee, J. F., K. J. O'Farrell, P. Reitsma, and R. Mehra. 1996. Effect of a whey protein concentrate used as a colostrum substitute or supplement on calf immunity, weight gain, and health. J. Dairy Sci. 79 : 886-894.
  46. Mollerberg, L., Ekman, L. and Jacobsson, S. O. 1975. Plasma and blood volume in the calf from birth till 90 days of age. Acta Vet. Scand. 16 : 178.
  47. Muller, L. D. and Ellinger, D. K. 1981. Colostral immunoglobulin concentrations among breeds of dairy cattle. J. Dairy Sci. 64 : 1727-1730.
  48. Nardone, A., N. Lacetera, U. Bernabucci, and B. Ronchi. 1997. Composition of colostrums from dairy heifers exposed to high air temperatures during late pregnancy and the early postpartum period. J. Dairy Sci. 80 : 838-844.
  49. National Animal Health Monitoring Service. National Dairy Heifer Evaluation Project. Dairy heifer morbidity, mortality, and health management focusing on preweaned heifers. USDAAPHIS-VS. 1994.
  50. National Animal Health Monitoring System. 1993. Dairy herd management practices focusing on preweaned heifers. USDA, Animal and Plant Health Inspection Service, Veterinary Services, Fort Collins, CO.
  51. Norcross, N. L. 1982. Secretion and composition of colostrum and milk. JAVMA. 181 : 1057-1060.
  52. Odle, J., R. T. Zijlstra, and S. M. Donovan. 1996. Intestinal effects of milkborne growth factors in neonates of agricultural importance. J. Anim. Sci. 74 : 2509-2522.
  53. Olson, D. P., Papasian, C. J. and Ritter, R. C. 1980. The effects of cold stress on neonatal calves. II. Absorption of colostrum immunoglobulins. Can. J. Comp. Med. 44 : 19.
  54. Olson, D. P., Woodward, L. F., Bull, R. C. and Everson, D. O. 1981. Immunoglobulin levels in serum and colostral whey of protein-metabolizable energy restricted beef cows. Res. Vet. Sci. 30 : 49.
  55. Oyeniyi, O. O. and A. G. Hunter. 1978. Colostral constituents including immunoglobulins in the first three milkings postpartum. J. Dairy Sci. 61 : 44-48.
  56. Pare, J., Thurmond, M. C., Gardner, I. A. and Picanso, J. P. 1993. Effect of birth weight, total protein, serum IgG and packed cell volume on risk of neonatal diarrhea in calves on two California dairies. Can. J. Vet. Res. 57 : 241-246.Parrish, D. B., G. H. Wise, J. S. Hughes, and F. W. Atkeson. 1950. Properties of the colostrum of the dairy cow V. Yield, specific gravity and concentrations of total solids and its various components of colostrum and early milk. J. Dairy Sci. 33 : 457-465.
  57. Payne, E., J. W. Ryley, and R. J. W. Gartner. 1967. Plasma, blood and extracellular fluid volumes in grazing Hereford cattle. Res. Vet. Sci. 8 : 20-26.
  58. Pederson, R. E., C. O. Paulrud, and W. B. Tucker. 2000. Influence of bovine antiserum (Bo- Bac 2X) injection on colostral immunoglobulin G absorption in neonatal dairy calves. J. Dairy Sci. 83: 2829-2833.
  59. Petrie, L. 1984. Maximising the absorption of colostral immunoglobulins in the newborn dairy calf. Vet. Rec. 114 : 157-163.
  60. Pritchett, L. C., C. C. Gay, T. E. Besser, and D. D. Hancock. 1991. Management and production factors influencing immunoglobulin G1 concentration in colostrum from Holstein cows. J. Dairy Sci. 74 : 2336-2341.
  61. Quigley, J. D. and Drewry, J. J. 1998. Nutrient and immunity transfer from cow to calf pre and post calving. J. Dairy Sci. 81: 2779- 2790.
  62. Quigley, J. D., III and M. G. Welborn. 1996. Influence of injectable immunoglobulin on serum immunoglobulin concentrations in dairy calves. J. Dairy Sci. 79 :2032-2037.
  63. Quigley, J. D., III, D. L. Fike, M. N. Egerton, J. J. Drewry, and J. D. Arthington. 1998. Effects of a colostrum replacement product derived from serum on immunoglobulin G absorption by calves. J. Dairy Sci. 81 :1936-1939.
  64. Quigley, J. D., III, P. French, and R. E. James. 2000. Effect of pH on absorption of immunoglobulin G in neonatal calves. J. Dairy Sci. 83 : 1853-1855.
  65. Rajaraman, V., Nonneck, B.J. and Horst, R.L. 1997. Effect of replacement of native fat in colostrum and milk with coconut oil on fat soluble vitamins in serum and immune function in calves. J. Dairy Sci. 80 : 2380-2390.
  66. Rea, D. E., Tyler, J. W., Hancock, D. D., Besser, T. E., Wilson, L., Krytenberg, D. S. and Sanders, S. G. 1996. Prediction of calf mortality by use of tests for passive transfer of colostral immunoglobulin. JAVMA. 208: 2047-2049.
  67. Reiter, B. 1978. Review of nonspecific antimicrobial factors in colostrum. Ann. Rech. Vet. 9: 205-224.
  68. Rensbaw, H. W., Eckblad, W. P., Everson, D. O., Tassinari, P. D. and Amos, D. 1977. Ontogeny of immnnocompetence in cattle: evaluation of phytomitogen induced in vitro bovine fetal lymphocyte blastogenesis, using a whole blood culture technique. Am. J. Vet. Res. 38 : 1141-1150.
  69. Roitt, I. M., J. Brostoff, and D. K. Male. 1998. Immunology. 5th ed. Mosby International Ltd., London, United Kingdom. Pages 72-76.
  70. Roy, J. H. B. 1980. Factors affecting susceptibility of calves to disease. J. Dairy Sci. 63 : 650-664.
  71. Roy, J. H. B. 1990. The Calf. Vol. 1, 5th ed. Butterworths, London.
  72. Senger, P. L. 1997. In Pathways to Pregnancy and Parturition. 1st ed. Current Conceptions, Inc., Pullman, WA, pp. 236-238.
  73. Seymour, W. M., J. E. Nocek, and J. Siciliano-Jones. 1995. Effects of a colostrum substitute and of dietary brewer's yeast on the health and performance of dairy calves. J. Dairy Sci. 78 : 412-420.
  74. Shearer, J., H. O. Mohammed, J. S. Brenneman, and T. Q. Tran. 1992. Factors associated with concentrations of immunoglobulins in colostrum at the first milking post-calving. Prevent. Vet. Med. Ser. A. 14 : 143-154.
  75. Singh, A. K. 2010. Studies on immune functions and metabolic status of growing buffalo calves in response to colostral immunoglobulins. M.V.Sc. Thesis submitted to NDRI Deemed Univerisity, Karnal (Haryana), India.
  76. Singh, A., Ahuja, S. P., Singh, B. 1992. Individual variation in the composition of colostrum and absorption of colostral antibodies by the precolostral buffalo calf. J. Dairy Sci. 76 : 1148-1156.
  77. Staley, T.E., L.D. Corley, L.J. Bush, and E.W. Jones. 1972. The ultrastructure of neonatal calf intestine and absorption of heterologous proteins. Anat. Rec. 172 : 559-580.
  78. Stott, G. H., and Fellah, A. 1983. Colostral immunoglobulin absorption linearly related to concentration for calves. J. Dairy Sci. 66: 1319-1328.
  79. Stott, G. H., Marx, D. B., Menefee B. E. and Nightengale, G. T. 1979b. Colostral immunoglobulin transfer in calves III. Amount of absorption. J. Dairy Sci., 62 : 1902-1907.
  80. Stott, G. H., Marx, D. B., Menefee B. E. and Nightengale, G. T. 1979a. Colostral immunoglobulin transfer in calves I. Period of absorption. J. Dairy Sci., 62 : 1632-1638.
  81. Stott, G. H., W. A. Fleenor, and W. C. Kleese. 1981. Colostral immunoglobulin concentration in two fractions of first milking postpartum and five additional milkings. J. Dairy Sci. 64 : 459-465.
  82. Todd, A. G., P. B. D. Whyte, and P. D. Carroll. 1993. A comparison of serum immunoglobulin concentrations in neo-natal calves fed substitute colostrums. Aust. Vet. J. 70: 154-155.
  83. Van de Perre, P. 2003. Transfer of antibody via mother's milk. Vaccine. 21: 3374-3376.
  84. Weaver, D. M., Tyler, J. W., VanMetre, D. C., Hostetler, D. E. and Barrington G. M. 2000. Passive transfer of colostral immunoglobulins in calves. J. Vet. Intern. Med. 14: 569-577.
  85. Westrom, B. R., Svendsen, J., Ohlsson, B. G., Tagesson, C. and Karlsson B. W. 1984. Intestinal transmission of macromolecules (BSA and HTC-labelled dextran) in the neonatal pig: influence of age of piglet and molecular weight of marker. Biol. Neonate. 46: 20.
  86. White, D. G. 1993. Colostral supplementation in ruminants. Compend. Cont. Educ. Pract. Vet. 15 : 335-342.
  87. Xu, R. J. 1996. Development o the newborn GI tract and its relation to colostrum/milk intake: a review. Reprod. Fertil. Dev. 8 : 35-48.
  88. Zaremba, W., W. M. Guterbock, and C. A. Holmberg. 1993. Efficacy of a dried colostrums powder in the prevention of disease in neonatal Holstein calves. J. Dairy Sci. 76 :831-836.
  89. Zaugg, J. L. 1994. Bovine plasma transfusions for sustained serum immunoglobulin concentrations in colostrum-deprived calves. Agri-Practice. 15: 35-39.

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