Agricultural Reviews

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Agricultural Reviews, volume 33 issue 3 (september 2012) : 220 - 225

STUDY OF TOLL-LIKE RECEPTORS 4 (TLR4) GENE IN CATTLE: A REVIEW

S. Rajesh Wakchaure, I.D. Gupta, Archana Verma, S. Rajesh Kumar, Dinesh Kumar*
1Dairy Cattle Breeding Division, National Dairy Research Institute, Karnal- 132 001, India

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Cite article:- Wakchaure Rajesh S., Gupta I.D., Verma Archana, Kumar Rajesh S., Kumar* Dinesh (2024). STUDY OF TOLL-LIKE RECEPTORS 4 (TLR4) GENE IN CATTLE: A REVIEW. Agricultural Reviews. 33(3): 220 - 225. doi: .

ABSTRACT

Toll-like receptors 4 (TLR4) is the only important pattern recognition receptor of the TLRs family that recognizes endotoxins associated with gram-negative bacterial infections. TLR4 plays a pivotal role in linking innate and adaptive immunity. Bovine mRNA of TLR4 gene was isolated by RT-PCR and was quantified by real-time PCR and in situ hybridization. Increased mRNA expression of TLR4 gene in the infected mammary gland with mastitis caused by either Staphylococcus aureus (S. aureus) or E. coli thereby suggesting that TLR4 gene might be related with mastitis.

REFERENCES

  1. Anderson, K.V., Jurgens, G. and Nusslein-Volhard, C. (1985). Establishment of dorsalventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product. Cell, 42: 779-789.
  2. Bannerman, D.D., Paape, M.J., Hare, W.R., and Sohn, E.J. (2003). Increased levels of LPS-binding protein in bovine blood and milk following bacterial lipopolysaccharide challenge. J. Dairy Sci., 86: 3128–3137.
  3. Beutler, B. (2005). The Toll-like receptors: analysis by forward genetic methods. Immunogenetics , 57: 385–392.
  4. Bilak, H.S., Delamasure, T. and Imler, J.L. (2003). Toll and Toll-like receptors in Drosophila. Biochem. Soci. Transa, 31(3):648-651.
  5. Donald, N.C., David, S.P. and David, A.S. (2004). Toll-like receptors in the pathogenesis of human disease. Nat. Immunol., 10: 975-979.
  6. Fan, J. and Malik, A.B. (2003). Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptors. Nat. Med., 9: 315-321.
  7. Ferwerda, G., Kullberg, B.J., Jong, D.J., Girardin, S.E. and Langenberg, D.M. (2007). Mycobacterium paratuberculosis is recognized by Toll-like receptors and NOD2.J. Leukoc Biol., 82:1011–1018.
  8. Goldammer, T., Zerbe, H., Molenaar, A., Schuberth, H.J., Brunner, R.M., Kata, S.R. and Seyfert, H.M. (2004). Mastitis increases mammary mRNA abundance of beta defensin 5, toll-like-receptor 2 (TLR 2), and TLR4 but not TLR9 in cattle. Clin. Diagn. Lab Immunol., 11:174–185.
  9. Griesbeck-Zilch, B., Meyer, H.H.D., Kuhn, C.H., Schwerin, M. and Wellnitz, O. (2008). Staphylococcus aureus and Escherichia coli cause Deviating Expression Profiles of Cytokines and Lactoferrin Messenger Ribonucleic Acid in Mammary Epithelial Cells. J. Dairy Sci., 91:2215-2224.
  10. Gonen, E., Vallon-Eberhard, A., Elazar ,S., Harmelin, A., Brenner, O., Rosenshine, I., Jung, S., Shpigel, N.Y. (2007).Toll- like receptor 4 is needed to restrict the invasion of Escherichia coli P4 into mammary gland epithelial cells in a murine model of acute mastitis, Cell. Microbiol., 9: 2826–2838.
  11. Hill, A. W. (1981). Factors influencing the outcome of Escherichia coli mastitis in the dairy cow. Res. Vet. Sci., 31:107–112.
  12. Hoffmann, J. A. and Reichhart, J. M. (2002). Drosophila innate immunity: an evolutionary perspective. Nat. Immunol., 3: 121–126.
  13. Imler, J.L. and Zheng, L. (2004). Biology of Toll receptors: lessons from insects and mammals. J. Leukoc Biol., 75:18-26.
  14. Jilling, T., Simon, D., Lu, J., Meng, F.J., Li, D., Schy, R., Thomson, R.B., Soliman, A., Arditi, M. and Caplan, M.S. (2006). The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis .J. Immuno.,
  15. 177: 3273–3282.
  16. Jin, M.S., Kim, S.E., Heo, J.Y., Lee, M.E., Kim, H.M., Paik, S.G., Lee, H. and Lee, J.O. (2007).Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell, 130: 1071-1082.
  17. Kataria, R. S., Richard, G.T., Kumar, D., Manuel, A., Ortega, J.R. and James, M. R. (2010). Association of toll-like receptor four single nucleotide polymorphisms with incidence of infectious bovine keratoconjunctivitis (IBK) in cattle. Immunogenetics; DOI 10.1007/s00251-010-0484-6.
  18. Kurt-Jones, E.A., Popova, L., Kwinn, L., Haynes, L.M. and Jones, L.P. (2000). Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat. Immunol., 1: 398–401.
  19. Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J. M. and Hoffmann, J. A. (1996). The dorsoventral regulatory gene cassette spatzle/toll/cactus control the potent antifungal response in drosophila adult. Cell, 86: 973–983.
  20. Li, Y. and Ning, Y.S. (2004). Toll like receptors and immunity. Fore Med Sci. Select Immunol, 27(4): 228-230 (in Chinese with an English abstract).
  21. Lorenz, E., Mira, J.P., Frees, K.L. and Schwartz, D.A. (2002). Relevance of mutationsin the TLR4 receptor in patients with gram-negative septic shock. Arch Intern Med., 162:1028–1032.
  22. Malley, R., Henneke, P., Morse, S.C., Cieslewicz, M. J., Lipsitch, M., Thompson, C. M., Kurt-Jones, E., Paton, J. C., Wessels, M. R. and Golenbock, D. T. (2003). Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc. Natl. Acad. Sci. USA., 100: 1966–1971.
  23. McGuire, K., Jones, M., Werling, D., Williams, J.L., Glass, E.J. and Jann, O. (2005). Radiation hybrid mapping of all 10 characterized bovine Toll-like receptors, Anim. Genet., 37: 47–50.
  24. Miller, S.I., Ernst, R. K. and Bader M.W. (2005). LPS, TLR4 and infectious disease diversity, Nat. Rev. Microbiol., 3:36–46.
  25. Morisato D. and Anderson K. V. (1995). Signaling pathways that establish the dorsalventral pattern of the Drosophila embryo. Annu. Rev Genet., 29: 371-399.
  26. Mucha, R., Bhide, M.R., Chakurkar, E.B. and Mikula, N. M. (2009). Toll like receptors TLR1, TLR2 and TLR4 gene mutations and natural resistance to Mycobacterium avium subsp. paratuberculosis infection in cattle. Vet. Immunol Immunopathol .,28:381–388.
  27. Muzio, M., Bosisio, D., Polentarutti, N., D’amico, G., Stoppacciaro, A., Mancinelli, R., Veer C., Penton Rol, G., RucoAllavena, L.P. and Mantovani, A.(2000). Differential expression and regulation of Toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J. Immunol., 164:5998.
  28. Ogorevc, J., Kunej, T., Razpet, A. and Dovc, P. (2009). Database of cattle candidate genes and genetic markers for milk production and mastitis. Anim. Genet, 40: 832–851.
  29. Opsal, M.A., Lien, S., Brenna-Hansen, S., Olsen, H.G. and Vage, D.I. (2008). Association analysis of the constructed linkage maps covering TLR2 and TLR4 with clinical mastitis in Norwegian Red cattle. J. Anim. Breed.Genet., 125:110–118.
  30. Petzl, W., Zerbe, H., Günther, J.,Yang, W., Seyfert, H.M., Nürnberg, G. and Schuberth, H.J. (2008) .Escherichia coli, but not Staphylococcus aureus triggers an early increased expression of factors contributing to the innate immune defense in the udder of the cow. Vet Res., 39:18.
  31. Reinhardt , T.A. and Lippolis, J.D. (2006). Bovine milk fat globule membrane proteome, J. Dairy Res., 73:406–416.
  32. Riollet, C., Rainard, P. and Poutrel, B. (2000). Cells and cytokines in inflammatory secretions of bovine mammary gland. Adv. Exp. Med. Biol., 480:247–258.
  33. Roach. J.C., Glusman. G., Rowen. L., Kaur A., Purcell. M.K., Smith. K.D, Hood .L.E. and Aderem, A. (2005). The evolution of vertebrate Toll-like receptors. Proc. Natl. Acad. Sci., 102:9577–9582.
  34. Sabroe, I., Lynne, R.P., Jones, E.C., Horsburgh , M. J., Foster, S.J., Vogel, S.N., Dower ,S. K. and Whyte, M. K.B. (2003). Selective Roles for Toll-Like Receptor (TLR) 2 and TLR4 in the Regulation of Neutrophil Activation and Life Span. J. Immunol., 70: 5268–5275.
  35. Schepper De, S., De Ketelaere, A., Bannerman, D.D., Paape, M.J., Peelman, L. and Burvenich, C. (2008). The Toll-like receptor-4 (TLR-4) pathway and its possible role in the pathogenesis of Escherichia coli mastitis in dairy cattle. Vete. Res.., 39(1) :( article #5)1-23.
  36. Sharma, B.S., Leyva, I., Schenkel, F. and Karrow, N.A. (2006). Association of Toll- Like Receptor 4 Polymorphisms with Somatic Cell Score and Lactation Persistency in Holstein Bulls. J. Dairy Sci., 89:3626–3635.
  37. Shook, G.E., and Schutz, M. M. (1993). Selection on somatic cell score to improve resistance to mastitis in the United States. J. Dairy Sci., 77:648–658.
  38. Smirnova, I., Hamblin, M.T., McBride, C., Beutler, B. and Rienzo, A. (2001). Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans. Genetics., 158: 1657–1664.
  39. Sonawane, G.S. (2009). Molecular characterization of toll –like receptor -4 (TLR4) genes in Murrah buffalo (Bubalus bubalis). MVSc Thesis , NDRI, Karnal, India.
  40. Takeda, K., Kaisho, T. and Akira, S. (2003). Toll-like receptors. Annu. Revi. Immunology., 21: 335-376.
  41. Trinchieri, G. and Sher, A. (2007). Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol., 7:179–190.
  42. Wakchaure (2010). Genetic polymorphism of toll - like receptor 4 gene and its association with mastitis in sahiwal cattle. Ph.D. Thesis, NDRI, Karnal, India.
  43. Wang, X., Luoreng, Z., Xu, S., Gao, X., Li, J., Ren, H. and Chen, J. (2009). The structure and sequence analysis of TLR4 gene in cattle. Agr Sci China., 8:632–637.
  44. Wang, X., Moser, C., Louboutin, J.P., Lysenko, E.S., Weiner, D.J., Weiser, J.N .and Wilson, J.M., (2002). Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lung. J. Immunol., 168:810–815.
  45. Wang, X.P., Xu, S.Z., Ma, T.H., Gao, X., Ren, H.Y. and Chen, J.B. (2006). Genetic variation in the 5' flanking region of bovine TLR4 gene and correlation with mastitis. Yi Chuan., 28(12):1520-1540.
  46. Wang, X., Xu, S., Xue, S., Ren, H. and Chen, J. (2007). Genetic Polymorphism of TLR4 Gene and Correlation with Mastitis in Cattle. Journal of Genetics and Genomics, 34(5): 406-412.
  47. Wang ,X., Xu, S., Xue, G., Li, J., Ren, H.and Luoren, Z. (2008). Cloning and SNP screening of the TLR4 gene and the association between its polymorphism and somatic cell score in dairy cattle. South African J. Anim. Scie., 38 (2):101-109.
  48. White, S.N., Taylor, K.H., Abbey, C.A., Gill, C.A. and Womack, J.E.(2003).Haplotype variation in bovine Toll-like receptor 4 and computational prediction of a positively selected ligand-binding domain. Proc. Natl. Acad. Sci., 100: 10364-10369.
  49. Weiss, D.J., Souza, C.D., Evanson, O.A., Sanders, M. and Rutherford, M. (2007). Bovine monocyte TLR2 receptors differentially regulate the intracellular fate of Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium. J. Leukoc. Biol., 83: 48–55.
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