Vegetable crops are attacked by large number of diseases. Control of these diseases through the agronomical measures and chemical control leads to several disadvantages like higher cost of production, environmental pollution, development of vector resistance to the fungicides and some times chemicals has carcinogenic effect to the human being. Hence development of multiple disease resistant variety is only solution to overcome these problems. In the literature different genetic sources having resistance to important diseases of different vegetables have been reported. The inheritance of resistance to different diseases is may be of monogenic or oligogenic or polygenic in nature. When resistance is governed by single dominant gene. It is very easy to exploit it in heterosis breeding programme. The back cross method is generally used to transfer such type of resistance. When resistance is governed by polygenes generally pedigree method is followed to select resistant plants in the segregating generations. For accumulating more number of resistant genes in to a single cultivar, three way or double crosses are followed. The most important multiple disease resistant varieties include Rodade. Florida-11011 of tomato, JP-9 and JP-179 varieties of pea, Arka Manik of water melon, Punjab Lal and CH-1 (F1) of chilli which has resistance against two or more diseases.