Indian Journal of Animal Research

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Research Article

Indian Journal of Animal Research, volume 53 issue 6 (june 2019) : 827-831

Comparison of the clinical effects of Prednisolone, Azathioprine and Oligodeoxynucleotide (ODN) applications in experimentally induced endotoxin uveitis in rats

Tuba Özge Yaşar Erkal, Servet Kılıç, Fatih Hatipoğlu, Funda Terzi
1Namik Kemal University, Faculty of Veterinary Medicine, Department of Surgery, Degirmenaltý Campus, 59030 Suleymanpasa, Tekirdag, Turkey.
Cite article:- Erkal Yaşar Özge Tuba, Kılıç Servet, Hatipoğlu Fatih, Terzi Funda (2018). Comparison of the clinical effects of Prednisolone, Azathioprine and Oligodeoxynucleotide (ODN) applications in experimentally induced endotoxin uveitis in rats. Indian Journal of Animal Research. 53(6): 827-831. doi: 10.18805/ijar.B-924.

ABSTRACT

Clinical effects and pathological changes of synthetic oligodeoxynucleotide (ODN), prednol (PRD) and azathioprine (AZA) was compared on uveitis treatment in rats. A total of 28 Wistar Albino, female, adult rats were divided into Control (C), PRD, AZA and ODN groups. Uveitis was induced by 176 ìg/rat subcutan injection E. coli, LPS and observed in all animals after 48 hours. Then, 0.25 mg/rat/day AZA and 1.25 mg/rat/day of methylprenidolone was administered by gavage in AZA and PRD groups for ten days. In the ODN group, 178 ìg/rat ODN was administered IP totally four times. A numerical weight loss was seen in all groups in the course of the infection period, but dropped dramatically in the PRD group during the treatment period. Average value of right and left eye results showed that immunesuppressive effect of Prednol was higher in terms of IOP values compared to others whereas Shirmer test values were the lowest in the post-treatment period. Finally, Prednol was more effective with its immunesuppressive effect resulting in recovery of photophobia, vascularization and oedema in iris vessels. 

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