Indian Journal of Animal Research

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Research Article

Indian Journal of Animal Research, volume 52 issue 10 (october 2018) : 1413-1415

Novel SNP and Unique Sequences in ATP-binding Cassette Super Family-G Member-2 Transporter (ABCG2) Gene of  Vechur cattle (Bos indicus)

F.A. Lali, K. Anilkumar, T.V. Aravindakshan
1Department of Animal Breeding, Genetics and Biostatistics, College of Veterinary and Animal Sciences, Mannuthy, Thrissur-680 651, Kerala, India.
Cite article:- Lali F.A., Anilkumar K., Aravindakshan T.V. (2018). Novel SNP and Unique Sequences in ATP-binding Cassette Super Family-G Member-2 Transporter (ABCG2) Gene of Vechur cattle (Bos indicus). Indian Journal of Animal Research. 52(10): 1413-1415. doi: 10.18805/ijar.B-3399.

ABSTRACT

In the present study, ABCG2 gene of Vechur cattle of Kerala was sequenced and aligned using Basic Local Alignment Search Tool (BLAST) in National Centre for Biotechnology Information (NCBI) site.  The results revealed that ABCG2 gene sequence of Vechur  cattle shows 96% similarity with reference  NCBI sequences.  Addition of eleven base pairs in 13th intron in ABCG2 gene of Vechur cattle which derived a larger amplicon (303 bp) than expected (292 bp).  A novel SNP (G4104A) was identified at 4104th position in intron 13 of ABCG2 gene of Vechur cattle. Further research is suggested to depict the association if any of the novel SNP and unique characters of Vechur cattle.

REFERENCES

  1. Cohen M, Seroussi E and Band M. 2004.SPP1 is a candidate gene for the QTLAffecting milk protein concentration onBTA-6 Based on population-wide linkagedisequilibrium, differential expression, andtargeted inhibition. Proceedings of 29th Conference of theInternational Society for Animal Genetics,Tokyo, Japan, PP. 112.
  2. Cohen-Zinder M, Seroussi E, Larkin, D M, Loor J J, Wind A E, Lee J H, Drackley J K, et al. (2005). Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6affecting milk yield and composition in Holstein cattle. Genome Res., 15:936–44
  3. Islam, S., Goswami, A. and Mazumdar, D. (2008). Comparative profitability of cross breed and Indigenous cattle in West Bengal. Indian Res. J. Ext. Edu. 8 (1): 28-30
  4. Khatkar M S, ThomsonP C, TammenI and Raadsma H W. (2004). Quantitative trait loci mapping in dairy cattle: Review and meta-    analysis. Genet. Sel. Evol. 36:163-190
  5. Kim J J, Farnir F, Savell J and Taylor J F (2003) Detection of quantitative trait loci for growth and beef carcass fatness traits in a cross between Bos Taurus (Angus) and Bos indicus (Brahman) cattle. J. Anim. Sci. 81:1933-1942
  6. Komisarek J and Dorynek Z. (2009). Effect of ABCG2, PPARGC1A, OLR1 and SCD1 gene polymorphism on estimated breeding values for functional and production traitsin Polish Holstein-Friesian bulls. J. Appl. Genet. 50(2): 125–132
  7. Leslie E M, Deeley R.G and Cole S.P (2005). Multidrug resistance proteins: Role of P-Glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol. Appl. Pharmacol.204:216–237.
  8. Mousavizadeh S A, Salehi A, Aminafshar M, Sayyadnejad B and Nazemshirazi M H. (2013). Novel SNPs of the ABCG2 Gene and their associations withmilk production traits in Iranian Holstein bulls J. Agr. Sci. Tech. 15: 1145-1151
  9. Olsen H G, Lien S, Gautier M, Nilsen H, Roseth A, Berg P R, Sundsaasen K K, Svendsen M and Meuwissen T H. (2005). Mapping of a milk production quantative trait locus to a 420-Kb region on bovine chromosome 6. Genetics 169:275-283 
  10. Olsen H G, Nilsen H, Hayes B, Berg PR, Svendsen M, Lien S and MeuwissenT. (2007). Genetic support for a quantitative trait nucleotide in the ABCG2GeneAffecting the milk composition of dairy cattle. BMC Genetics, 8: 32
  11. Sambrook J and Russel D W. (2001). Molecular cloning: a Laboratory Mannual. Third edition. Cold Spring Harbor Laboratory Press. New York, P. 1886 
  12. Weikard R, Kuhn C, Goldammer T, Freyer G and Schwerin M. (2005). The Bovine PPARGC1A Gene: Molecular Characterization and Association of an SNP with Variation of Milk Fat Synthesis.Physiol. Genom., 21: 1–3
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